abstract：:This study shows that sequential introduction of drug resistance mutations substantially increased enzyme production in Paenibacillus agaridevorans The triple mutant YT478 (rsmG Gln225→stop codon, rpsL K56R, and rpoB R485H), generated by screening for resistance to streptomycin and rifampin, expressed a 1,100-fold-lar...

journal_title：Journal of bacteriology

authors： Funane K,Tanaka Y,Hosaka T,Murakami K,Miyazaki T,Shiwa Y,Gibu S,Inaoka T,Kasahara K,Fujita N,Yoshikawa H,Hiraga Y,Ochi K

更新日期：2018-08-10 00:00:00

abstract：:The 6th American Society for Microbiology Conference on Cell-Cell Communication in Bacteria convened from 16 to 19 October 2017 in Athens, GA. In this minireview, we highlight some of the research presented at that meeting that addresses central questions emerging in the field, including the following questions. How a...

journal_title：Journal of bacteriology

authors： Brown SP,Blackwell HE,Hammer BK

更新日期：2018-06-25 00:00:00

abstract：:The Dps-like peroxide resistance protein (Dpr) is essential for H2O2 stress tolerance and aerobic growth of the oral pathogen Streptococcus mutans Dpr accumulates during oxidative stress, protecting the cell by sequestering iron ions and thereby preventing the generation of toxic hydroxyl radicals that result from the...

journal_title：Journal of bacteriology

authors： Ganguly T,Kajfasz JK,Miller JH,Rabinowitz E,Galvão LCC,Rosalen PL,Abranches J,Lemos JA

更新日期：2018-06-25 00:00:00

abstract：:Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the resistance-nodulation-cell division (RND) superfamily of transporters. In this study, we analy...

journal_title：Journal of bacteriology

authors： Leus IV,Weeks JW,Bonifay V,Smith L,Richardson S,Zgurskaya HI

更新日期：2018-06-11 00:00:00

abstract：:The RNA polymerase (RNAP) binding protein A (RbpA) contributes to the formation of stable RNAP-promoter open complexes (RPo) and is essential for viability in mycobacteria. Four domains have been identified in the RbpA protein, i.e., an N-terminal tail (NTT) that interacts with RNAP β' and σ subunits, a core domain (C...

journal_title：Journal of bacteriology

authors： Prusa J,Jensen D,Santiago-Collazo G,Pope SS,Garner AL,Miller JJ,Ruiz Manzano A,Galburt EA,Stallings CL

更新日期：2018-06-11 00:00:00

abstract：:The two-partner secretion system ExlBA, expressed by strains of Pseudomonas aeruginosa belonging to the PA7 group, induces hemorrhage in lungs due to disruption of host cellular membranes. Here we demonstrate that the exlBA genes are controlled by a pathway consisting of cAMP and the virulence factor regulator (Vfr). ...

journal_title：Journal of bacteriology

authors： Berry A,Han K,Trouillon J,Robert-Genthon M,Ragno M,Lory S,Attrée I,Elsen S

更新日期：2018-05-24 00:00:00

abstract：:Bacterial pathogenesis depends on changes in metabolic and virulence gene expression in response to changes within a pathogen's environment. The plague-causing pathogen, Yersinia pestis, requires expression of the gene encoding the Pla protease for progression of pneumonic plague. The catabolite repressor protein Crp,...

journal_title：Journal of bacteriology

authors： Ritzert JT,Lathem WW

更新日期：2018-05-09 00:00:00

abstract：:The oral cavity is home to a wide variety of bacterial species, both commensal, such as various streptococcal species, and pathogenic, such as Porphyromonas gingivalis, one of the main etiological agents of periodontal disease. Our understanding of how these bacteria ultimately cause disease is highly dependent upon u...

journal_title：Journal of bacteriology

authors： Rocco CJ,Bakaletz LO,Goodman SD

更新日期：2018-05-09 00:00:00

abstract：:Corynebacterium diphtheriae, a Gram-positive, aerobic bacterium, is the causative agent of diphtheria and cutaneous infections. While mechanisms required for heme iron acquisition are well known in C. diphtheriae, systems involved in the acquisition of other metals such as zinc and manganese remain poorly characterize...

journal_title：Journal of bacteriology

authors： Peng ED,Oram DM,Battistel MD,Lyman LR,Freedberg DI,Schmitt MP

更新日期：2018-04-24 00:00:00

abstract：:Haloarchaea in their natural environment are exposed to hypersalinity, intense solar radiation, and desiccation, all of which generate high levels of oxidative stress. Previous work has shown that haloarchaea are an order of magnitude more resistant to oxidative stress than most mesophilic organisms. Despite this resi...

journal_title：Journal of bacteriology

authors： Gelsinger DR,DiRuggiero J

更新日期：2018-04-09 00:00:00

abstract：:HetR plays a key role in regulation of heterocyst differentiation and patterning in Anabaena It directly regulates genes involved in heterocyst differentiation (such as hetP and hetZ), genes involved in pattern formation (patA), and many others. In this study, we investigated the functional relationship of hetP and he...

journal_title：Journal of bacteriology

authors： Zhang H,Wang S,Wang Y,Xu X

更新日期：2018-04-09 00:00:00

abstract：:The DNA binding protein WhiA is conserved in Gram-positive bacteria and is present in the genetically simple cell wall-lacking mycoplasmas. The protein shows homology to eukaryotic homing endonucleases but lacks nuclease activity. WhiA was first characterized in streptomycetes, where it regulates the expression of key...

journal_title：Journal of bacteriology

authors： Bohorquez LC,Surdova K,Jonker MJ,Hamoen LW

更新日期：2018-03-26 00:00:00

abstract：:Vibrio cholerae is a natural inhabitant of aquatic ecosystems. Some strains of V. cholerae can colonize the human host and cause cholera, a profuse watery diarrhea. The major pathogenicity factors and virulence regulators of V. cholerae are either encoded in mobile genetic elements acquired in the environment (e.g. pa...

journal_title：Journal of bacteriology

authors： Sakib SN,Reddi G,Almagro-Moreno S

更新日期：2018-03-26 00:00:00

abstract：:Production of bacterial flagella is controlled by a multitiered regulatory system that coordinates the expression of 40 to 50 subunits and ordered assembly of these elaborate structures. Flagellar expression is environmentally controlled, presumably to optimize the benefits and liabilities of having these organelles o...

journal_title：Journal of bacteriology

authors： Markel E,Dalenberg H,Monteil CL,Vinatzer BA,Swingle B

更新日期：2018-03-12 00:00:00

abstract：:Most motile bacteria are able to bias their movement towards more favorable environments or to escape from obnoxious substances by a process called chemotaxis. Chemotaxis depends on a chemosensory system that is able to sense specific environmental signals and generate a behavioral response. Typically, the signal is t...

journal_title：Journal of bacteriology

authors： Ringgaard S,Yang W,Alvarado A,Schirner K,Briegel A

更新日期：2018-03-12 00:00:00

abstract：:In both prokaryotes and eukaryotes, hydroxyurea is suggested to inhibit DNA replication by inactivating ribonucleotide reductase and depleting deoxyribonucleoside triphosphate pools. In this study, we show that the inhibition of replication in Escherichia coli is transient even at concentrations of 0.1 M hydroxyurea a...

journal_title：Journal of bacteriology

authors： Nazaretyan SA,Savic N,Sadek M,Hackert BJ,Courcelle J,Courcelle CT

更新日期：2018-02-23 00:00:00

abstract：:The β-barrel assembly machinery (BAM) complex is the core machinery for the assembly of β-barrel membrane proteins, and inhibition of BAM complex activity is lethal to bacteria. Discovery of integral membrane proteins that are key to pathogenesis and yet do not require assistance from the BAM complex raises the questi...

journal_title：Journal of bacteriology

authors： Hay ID,Belousoff MJ,Dunstan RA,Bamert RS,Lithgow T

更新日期：2018-02-07 00:00:00

abstract：:Transmembrane bacterial chemoreceptors are extended, rod-shaped homodimers with ligand-binding sites at one end and interaction sites for signaling complex formation and histidine kinase control at the other. There are atomic-resolution structures of chemoreceptor fragments but not of intact, membrane-inserted recepto...

journal_title：Journal of bacteriology

authors： Akkaladevi N,Bunyak F,Stalla D,White TA,Hazelbauer GL

更新日期：2018-02-07 00:00:00

abstract：:Sinorhizobium meliloti is a soil-dwelling alphaproteobacterium that engages in a nitrogen-fixing root nodule symbiosis with leguminous plants. Cell surface polysaccharides are important both for adapting to stresses in the soil and for the development of an effective symbiotic interaction. Among the polysaccharides ch...

journal_title：Journal of bacteriology

authors： Barnett MJ,Long SR

更新日期：2018-01-10 00:00:00

abstract：:Attaching and effacing (AE) pathogens colonize the gut mucosa using a type three secretion system (T3SS) and a suite of effector proteins. The locus of enterocyte effacement (LEE) is the defining genetic feature of the AE pathogens, encoding the T3SS and the core effector proteins necessary for pathogenesis. Extensive...

journal_title：Journal of bacteriology

authors： Furniss RCD,Clements A

更新日期：2017-12-20 00:00:00

abstract：:The pst gene cluster encodes the phosphate-specific transport (Pst) system. Inactivation of the Pst system constitutively activates the two-component regulatory system PhoBR and attenuates the virulence of pathogenic bacteria. In uropathogenic Escherichia coli strain CFT073, attenuation by inactivation of pst is predo...

journal_title：Journal of bacteriology

authors： Crépin S,Porcheron G,Houle S,Harel J,Dozois CM

更新日期：2017-11-14 00:00:00

abstract：:Due in large part to their ability to facilitate the diffusion of a diverse range of solutes across the outer membrane (OM) of Gram-negative bacteria, the porins represent one of the most prominent and important bacterial membrane protein superfamilies. Notably, for the Gram-negative bacterium Desulfovibrio vulgaris H...

journal_title：Journal of bacteriology

authors： Zeng L,Wooton E,Stahl DA,Walian PJ

更新日期：2017-10-31 00:00:00

abstract：:Salmonella enterica can utilize fructose-asparagine (F-Asn) as a source of carbon and nitrogen. This capability has been attributed to five genes in the fra locus. Previously, we determined that mutations in fraB (deglycase), fraD (kinase), or fraA (transporter) eliminated the ability of Salmonella to grow on F-Asn, w...

journal_title：Journal of bacteriology

authors： Sabag-Daigle A,Sengupta A,Blunk HM,Biswas PK,Cron MC,Bogard AJ,Behrman EJ,Gopalan V,Ahmer BMM

更新日期：2017-10-17 00:00:00

abstract：:Vibrio vulnificus is an estuarine bacterium and potent opportunistic human pathogen. It enters the food chain by asymptomatically colonizing a variety of marine organisms, most notably oysters. Expression of the brp-encoded extracellular polysaccharide, which enhances cell-surface adherence, is regulated by cyclic di-...

journal_title：Journal of bacteriology

authors： Chodur DM,Guo L,Pu M,Bruger E,Fernandez N,Waters C,Rowe-Magnus DA

更新日期：2017-09-05 00:00:00

abstract：:Bacteria of the genus Prosthecobacter express homologs of eukaryotic α- and β-tubulin, called BtubA and BtubB (BtubA/B), that have been observed to assemble into filaments in the presence of GTP. BtubA/B polymers are proposed to be composed in vitro by two to six protofilaments in contrast to that in vivo, where they ...

journal_title：Journal of bacteriology

authors： Díaz-Celis C,Risca VI,Hurtado F,Polka JK,Hansen SD,Maturana D,Lagos R,Mullins RD,Monasterio O

更新日期：2017-09-05 00:00:00

abstract：:RasP is a predicted intramembrane metalloprotease of Bacillus subtilis that has been proposed to cleave the stress response anti-sigma factors RsiW and RsiV, the cell division protein FtsL, and remnant signal peptides within their transmembrane segments. To provide evidence for direct effects of RasP on putative subst...

journal_title：Journal of bacteriology

authors： Parrell D,Zhang Y,Olenic S,Kroos L

更新日期：2017-09-05 00:00:00

abstract：:The ASM Conference on Mechanisms of Interbacterial Cooperation and Competition was held in Washington DC, from 1 to 4 March 2017. The conference provided an international forum for sociomicrobiologists from different disciplines to present and discuss new findings. The meeting covered a wide range of topics, spanning ...

journal_title：Journal of bacteriology

authors： Lories B,Parijs I,Foster KR,Steenackers HP

更新日期：2017-08-14 00:00:00

abstract：:The ability to restart broken DNA replication forks is essential across all domains of life. In Escherichia coli, the priA, priB, priC, and dnaT genes encode the replication restart proteins (RRPs) to accomplish this task. PriA plays a critical role in replication restart such that its absence reveals a dramatic pheno...

journal_title：Journal of bacteriology

authors： Leroux M,Jani N,Sandler SJ

更新日期：2017-08-08 00:00:00

abstract：:In order to analyze in molecular terms how Sulfolobus genomes diverge, damage-induced mutations and natural polymorphisms (PMs) were identified in laboratory constructs and wild-type isolates, respectively, of Sulfolobus acidocaldarius Among wild-type isolates drawn from one local population, pairwise nucleotide diver...

journal_title：Journal of bacteriology

authors： Mao D,Grogan DW

更新日期：2017-08-08 00:00:00

abstract：:A handful of nucleoid-associated proteins (NAPs) regulate the vast majority of genes in a bacterial cell. H-NS, the histone-like nucleoid-structuring protein, is one of these NAPs and protects Escherichia coli from foreign gene expression. Though lacking any sequence similarity with E. coli H-NS, Rv3852 was annotated ...

journal_title：Journal of bacteriology

authors： Odermatt NT,Sala C,Benjak A,Kolly GS,Vocat A,Lupien A,Cole ST

更新日期：2017-07-25 00:00:00

abstract：:Sporulation-related repeat (SPOR) domains are small peptidoglycan (PG) binding domains found in thousands of bacterial proteins. The name "SPOR domain" stems from the fact that several early examples came from proteins involved in sporulation, but SPOR domain proteins are quite diverse and contribute to a variety of p...

journal_title：Journal of bacteriology

authors： Yahashiri A,Jorgenson MA,Weiss DS

更新日期：2017-06-27 00:00:00

abstract：:Mutants of Bacillis subtilis that are temperature sensitive for RNA synthesis during sporulation were isolated after selection with a 32P suicide agent. Whole-genome sequencing revealed that two of the mutants carried an identical lesion in the rsbU gene, which encodes a phosphatase that indirectly activates SigB, the...

journal_title：Journal of bacteriology

authors： Rothstein DM,Lazinski D,Osburne MS,Sonenshein AL

更新日期：2017-06-27 00:00:00

abstract：:Cellular pigmentation is an important virulence factor of the oral pathogen Porphyromonas gingivalis Pigmentation has been associated with many bacterial functions, including but not limited to colonization, maintaining a local anaerobic environment by binding oxygen molecules, and defense against reactive oxygen spec...

journal_title：Journal of bacteriology

authors： Klein BA,Cornacchione LP,Collins M,Malamy MH,Duncan MJ,Hu LT

更新日期：2017-06-27 00:00:00

abstract：:Bacteria have evolved multiple strategies to sense and rapidly adapt to challenging and ever-changing environmental conditions. The ability to alter membrane lipid composition, a key component of the cellular envelope, is crucial for bacterial survival and adaptation in response to environmental stress. However, the p...

journal_title：Journal of bacteriology

authors： Rowlett VW,Mallampalli VKPS,Karlstaedt A,Dowhan W,Taegtmeyer H,Margolin W,Vitrac H

更新日期：2017-06-13 00:00:00

abstract：:In the nosocomial opportunistic pathogen Acinetobacter baumannii, RecA-dependent mutagenesis, which causes antibiotic resistance acquisition, is linked to the DNA damage response (DDR). Notably, unlike the Escherichia coli paradigm, recA and DDR gene expression in A. baumannii is bimodal. Namely, there is phenotypic v...

journal_title：Journal of bacteriology

authors： Ching C,Gozzi K,Heinemann B,Chai Y,Godoy VG

更新日期：2017-05-09 00:00:00

abstract：:FabG performs the NADPH-dependent reduction of β-keto acyl-acyl carrier protein substrates in the elongation cycle of fatty acid synthesis. We report the characterization of a temperature-sensitive mutation (fabGΔ8) in Escherichia colifabG that results from an in-frame 8-amino-acid residue deletion in the α6/α7 subdom...

journal_title：Journal of bacteriology

authors： Srinivas S,Cronan JE

更新日期：2017-04-25 00:00:00

abstract：:Gram-negative bacteria acquire ferric siderophores through TonB-dependent outer membrane transporters (TBDT). By fluorescence spectroscopic hgh-throughput screening (FLHTS), we identified inhibitors of TonB-dependent ferric enterobactin (FeEnt) uptake through Escherichia coli FepA (EcoFepA). Among 165 inhibitors found...

journal_title：Journal of bacteriology

authors： Nairn BL,Eliasson OS,Hyder DR,Long NJ,Majumdar A,Chakravorty S,McDonald P,Roy A,Newton SM,Klebba PE

更新日期：2017-04-25 00:00:00

abstract：:Bacterial cell division is a complex process that relies on a multiprotein complex composed of a core of widely conserved and generally essential proteins and on accessory proteins that vary in number and identity in different bacteria. The assembly of this complex and, particularly, the initiation of constriction are...

journal_title：Journal of bacteriology

authors： Osorio A,Camarena L,Cevallos MA,Poggio S

更新日期：2017-03-28 00:00:00

abstract：:ICE6013 represents one of two families of integrative conjugative elements (ICEs) identified in the pan-genome of the human and animal pathogen Staphylococcus aureus Here we investigated the excision and conjugation functions of ICE6013 and further characterized the diversity of this element. ICE6013 excision was not ...

journal_title：Journal of bacteriology

authors： Sansevere EA,Luo X,Park JY,Yoon S,Seo KS,Robinson DA

更新日期：2017-03-28 00:00:00

abstract：:Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, contains two immunodominant proteins, rOmpA and rOmpB, in the outer membrane. Both rOmpA and rOmpB are conserved throughout spotted fever group rickettsiae as members of a family of autotransporter proteins. Previously, it was demonstrated tha...

journal_title：Journal of bacteriology

authors： Noriea NF,Clark TR,Mead D,Hackstadt T

更新日期：2017-02-28 00:00:00